Sialylated structures are the major cancer-associated glycan alterations, including Thomsen–Friedenreich-associated antigens, sialyl Lewis antigens, α2,6-sialylated lactosamine, and gangliosides. This is due to an altered sialyltransferase expression in cancer. The presence of aberrantly sialylated structures on cell membrane receptors generates a flow of information toward the nucleus, which can exacerbate the neoplastic phenotype. offers a variety of Lectins to detect various sylylated structures associated with cancer biomarkers.

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