Affinity purified Succinylated concanavalin A (Succ-Con A) is derived from native lectin concanavalin A (Con A). It is a nonagglutinating lectin that has a carbohydrate specificity for α linked mannose and glucose, with a sugar elution of α-methlyglucoside + α-methlymannoside. Succ-Con A have been studied for their effects to induce marked proliferation of human peripheral blood lymphocytes. Succ-Con A exhibits mitogenic action equal to native Con A and both increase lymphocytes levels of cyclic GMP. Unlike Con A, Succ-Con at high concertation does not decrease mitogenic activity. Succ-Con A reversibly prevents the growth of normal cells and restores a normal growth phenotype to transformed cells.
Biotin is a small molecule involved in a wide range of metabolic processes. This ligand forms a complex with Avidin and Streptavidin, resulting in the strongest non-covalent protein-ligand interaction known. Biotinylated Succinylated Concanavalin A Lectin (Succ Con A) has an appropriate amount of biotin bound to provide optimum detection characteristics when using an Avidin-HRP or Streptavidin-HRP conjugate. Biotinylated lectins allow for more sensitive detection in ELISA and Western-blotting applications.