Sambucus nigra Lectin (SNA/EBL I) - Cy3

Sambucus nigra Lectin (SNA/EBL I) - Cy3
Sambucus nigra (Elderberry) Lectin (SNA/EBL I) - Cy3
Product image 1Sambucus nigra Lectin (SNA/EBL I) - Cy3
Product image 2Sambucus nigra (Elderberry) Lectin (SNA/EBL I) - Cy3

Price: Regular price $153.32

SKU#: 21761140-1

Product Description

Sambucus nigra Lectin (SNA/EBL I) is an isolectin isolated from elderberry bark and purified by affinity chromatography. SNA I belongs to the group of type 2 ribosome-inactivating proteins and is composed of an A-chain with enzymatic activity and a B-chain with carbohydrate-binding activity. It has specificity for α2,6-linked sialic acid residues, and elutes with the sugar lactose. SNA I can induce apoptosis through the caspase-dependent pathway at low concentrations. This effect depends on the carbohydrate binding of the B-chain and is independent from the catalytic activity of the A-chain.

Cy3 can be used to visualize the binding pattern of Sambucus nigra Lectin (SNA/EBL I) in cellular imaging and flow cytometry. Cy3 is more photostable than many other fluorophores and can be seen with TRITC filter sets. It is commonly combined with green-fluorescent dyes for dual-labeling.

Technical Specifications

Abbreviation: SNA/EBL I
Material Source:: Elderberry
Conjugate:: Cyanine 3 (Cy3)
Concentration:: 1 mg/mL
Shelf Life:: 1 year
Blood Group Specificity:: Non-specific
Preferred Sugar Specificity:: α2-6 Sialic Acid
Inhibiting or Eluting Sugar:: Lactose > β-Galactose
Fluorescence:: Orange
Divalent Ions:: None Required
Excitation:: 550 nm
Emission:: 570 nm
Mitogenic Activity:: Yes
Lyophilized or Liquid: Liquid
Storage Temperature:: 2-8°C
Hazardous Shipping:: Non-hazardous

Applications

References

  • Inoue K, Wada J, Eguchi J, Nakatsuka A, Teshigawara S, Murakami K, et al. (2013) Urinary Fetuin-A Is a Novel Marker for Diabetic Nephropathy in Type 2 Diabetes Identified by Lectin Microarray. PLoS ONE 8(10): e77118. https://doi.org/10.1371/journal.pone.0077118
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