Phaseolus vulgaris Lectin (PHA-L) - Macrobeads

Phaseolus vulgaris Lectin (PHA-L) - Macrobeads
Phaseolus vulgaris (Kidney bean) Lectin (PHA-L) - Macrobeads
Product image 1Phaseolus vulgaris Lectin (PHA-L) - Macrobeads
Product image 2Phaseolus vulgaris (Kidney bean) Lectin (PHA-L) - Macrobeads

Price: Regular price $98.04

SKU#: 21511135-1

Product Description

Phaseolus vulgaris lectin (PHA-L) is affinity purified lectin made up of four subunits with carbohydrate specificity for complex oligosaccharides. PHA-L is known as leucoagglutinin and has high mitogenic and leucoagglutinating activity, and low erythroagglutinating activity. This lectin exhibits no agglutination with human erythrocytes. PHA-E differs from PHA-L in that the leucoagglutinin reacts strongly with Tamm-Horsfall glycoprotein and reacts weakly with porcine thyroglobulin. PHA-L binds to fetuin but does not precipitate the glycoprotein. This lectin is strongly inhibited by trisaccharide Gal β(1,4)GlcNAcβ(1,2)Man, and although this structure is present in many glycoproteins, PHA-L does not react with all of them. This lectin reacts strongly with certain carcinoma cell lines of high metastatic potential and has been proposed as a probable therapeutic agent. It has shown potential to inhibit graft vs. host reaction in transplantation studies and has also shown to promote the production of cytotoxic agents which could be useful in cancer therapy.

Separopore® macrobeads are larger size (160-250 micron) than average agarose beads that facilitate coupling of cells and organelles and enzymes. Affinity-purified Phaseolus vulgaris Lectin (PHA-L) was immobilized on 4% agarose macrobeads with proper configuration and stability of the lectin.

Technical Specifications

Abbreviation: PHA-L
Material Source:: Red kidney bean seeds
Conjugate:: Macrobeads
Shelf Life:: 1 year
Blood Group Specificity:: Non-specific
Preferred Sugar Specificity:: Galß4GlcNAcß6(GlcNAcß2Manα3) Manα3, Oligosaccharides
Mitogenic Activity:: No
Lyophilized or Liquid: Liquid
Storage Temperature:: 2-8°C
Hazardous Shipping:: Non-hazardous

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