Paraformaldehyde is a common fixative reagent used in microscopy and immunohistochemistry. It immediately stops any ongoing biological processes and preserves the sample.
This 4% solution of Paraformaldehyde in PBS is ideal for fixing in cell culture. Simply apply directly to the sample and cool on ice for at least 10 minutes.
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See "Isolation of Cardiomyocytes from Fixed Hearts for Immunocytochemistry and Ploidy Analysis" by PubMed.