Iris hybrid Lectin (IRA) - Pure

Iris hybrid Lectin (IRA) - Pure

Price: Regular price $113.69

SKU#: 21510995-1

Product Description

Iris hybrid agglutinin (IRA) is isolated from dutch iris. IRA is a heterodimer that consists of two peptide chains, 27,000 and 34,000, linked by disulfide bonds. It has an isoelectric point between pH 7.2 and pH 7.4. This lectin agglutinates both native and trypsin-treated rabbit erythrocytes, not human erythrocytes, with specificity for blood group O and also agglutinates A and B erythrocytes.

IRA is N-acetylgalactosamine specific and elutes with sugar GalNAc?1-3Gal?-O. GalNAc ?1-3[L-Fuc ? 1-2]Gal and GalNAc ?1-3GalNAc are noninhibitory which suggests the importance of a free equatorial hydroxyl group at the C-2 position of the penultimate galactose for lectin binding. Either acetamido group or a fucosyl group at this position appears to cause steric hindrance, thus abolishing binding to the lectin.

This product comes in a lyophilized form and is stored at -20ë�C.

Technical Specifications

Abbreviation: IRA
Material Source:: Dutch iris
Conjugate:: None
Molecular Weight:: 61 kDa
Purity:: High Purity Grade
Shelf Life:: 2 years
Blood Group Specificity:: O>A>B
Preferred Sugar Specificity:: N-Acetylgalactosamine
Inhibiting or Eluting Sugar:: N-Acetylgalactosamine
Divalent Ions:: None Required
Lyophilized or Liquid: Lyophilized
Storage Temperature:: -20°C
Hazardous Shipping:: Non-hazardous

Applications

Agglutination studies

References

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