The Molecular Biology Fixative
Safe - Contains no formaldehyde, glutaraldehyde or mercury. Non-Toxic - Is completely odorless and can be safely disposed of down the drain.
HISTOCHOICE MB Tissue Fixative is the first fixative designed for the molecular biologist. It is specially formulated to preserve antigenic sites for antibody probes and nucleic acid sites for in situ hybridizations. HISTOCHOICE MB replaces formaldehyde based, alcohol based, Zenkers, B-5, B-3, Bouin's and other fixatives with superior results. Tissues fixed in HISTOCHOICE MB exhibit vibrant staining, better nuclear and cytoplasmic detail, and will retain a crisp appearance even after long term fixation. Because this formula is designed specifically for molecular biology applications, HISTOCHOICE MB fixed sections do not require pre-digestion or other recovery procedures to make important sites available. This means you spend less time preparing slides and more time doing research. More than a fixative, HISTOCHOICE MB is a preservative that leaves antigens and nucleic acids in their native state, allowing binding for specific probes. Primary antibodies can often be diluted several-fold due to the increased number of preserved antigenic sites, saving cost on every slide you process.
HISTOCHOICE MB fixed tissue retains a much more natural look and feel than formalin fixed tissue. Softer tissues mean easier, smoother cutting and sectioning. (Because soft tissues cut thinner than formalin-hardened samples, we recommend increasing microtome settings by 1-3 microns.) It is important to remember that these tissues are not fixed by formalin, but rather preserved by HISTOCHOICE MB.