Griffonia simplicifolia Lectin (GSL I) - Pure

Griffonia simplicifolia Lectin (GSL I) - Pure

Price: Regular price $89.70

SKU#: 21511060-1

Product Description

Griffonia simplicifolia lectin (GSL I) is affinity purified from a woody climbing shrub native to Africa. GSL I is composed of two types of subunits A and B that combine to form tetrameric structures, resulting in five isolectins. This lectin has affinity for terminal α-D-galactosyl residues and terminal N-acetyl-α-D-galactosaminyl residues. The A-rich lectin preferentially agglutinates blood group A erythrocytes and thus appears to be specific for α-N-acetylgalactosamine residues, while the B-rich lectin preferentially agglutinates blood group B cells and is specific for α-galactose residues. This lectin shows specificity for blood group B greater than blood group A1.
GSL I has been reported to bind several glycoproteins including laminin. Since some α-D-galactosyl residues are expressed in endothelial cells of mouse tissues, GSL I can present a highly specific surface of glycosylation pattern in these cells.

Technical Specifications

Abbreviation: GSL I
Material Source:: Bandeiraea
Conjugate:: None
Molecular Weight:: 114 kDa
Shelf Life:: 2 years
Blood Group Specificity:: B>A1
Preferred Sugar Specificity:: α-Galactose, α-N-Acetylgalactosamine
Inhibiting or Eluting Sugar:: Galactose, N-Acetylgalactosamine
Divalent Ions:: Ca++, Mn++
Mitogenic Activity:: No
Lyophilized or Liquid: Lyophilized
Storage Temperature:: -20°C
Hazardous Shipping:: Non-hazardous

Applications

Cancer biomarker, Glycobiology, Agglutination studies, IHC, ICC, IF, Blotting applciations, Endothelial cell marker for mice

References

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