Allium sativum lectin (ASA) is isolated from garlic and purified with affinity chromatography. It is a dimer of two subunits. ASA binds to a number of α1-2-linked mannose residues. The lectin recognizes internal mannose and binds to the core pentasaccharide of N-linked glycans. In addition, the removal of sialic acids enhances binding activity. ASA has shown antiproliferative and apoptosis-inducing activity, making it a relative subject in cancer research. This product comes in a lyophilized form and is stable for more than three years when stored below -20°C.
• Source: Allium sativum (Garlic)
• Activity: Agglutinates rabbit but not human erythrocytes.
• Carbohydrate Specificity: Mannose
• Inhibitory Carbohydrate: α(1,3)-Linked Mannosyl Units
• Mitogenic Activity: Yes
• Divalent Ions Required: None
Storage and Stability:
Store frozen at -20°C in amber vials or covered with foil in appropriate aliquot sizes. Avoid freeze thaw cycles. Can be stored at 2-8°C for short term use.