Sambucus nigra Lectin (SNA/EBL II) - Separopore® 4B

Sambucus nigra Lectin (SNA/EBL II) - Separopore® 4B
Sambucus nigra (Elderberry) Lectin (SNA/EBL II) - Separoporeëå 4B
Product image 1Sambucus nigra Lectin (SNA/EBL II) - Separopore® 4B
Product image 2Sambucus nigra (Elderberry) Lectin (SNA/EBL II) - Separoporeëå 4B

Price: Regular price $99.09

SKU#: 21511168-1

Product Description

Sambucus nigra lectin (EBL II/SNA II) isaffinity purified from elderberry bark. This lectin is a glycoprotein containing 7.8% carbohydrate and is not blood group specific. It is composed of two subunits and has a molecular weight of 140,000. EBL II has a specificity for carbohydrates containing terminal N-acetylgalactosamine and galactose residues.

The blood group A-active trisaccharide containing L-fucosyl group linked α1-2 to galactose is 10-fold lesser as an inhibitor than the parent oligosaccharide (GalNAc α1-3Gal), which suggests steric hindrance to binding by the α-L-fucosyl group and explains the failure of the lectin to exhibit blood group A specificity.

EBL II induces caspase-dependent apoptosis at low concentrations (nM) order, leading to typical symptoms of cell death in sensitive cells. This effect seems dependent on the carbohydrate binding B-chain.

Affinity purified Sambucus nigra Lectin (SNA/EBL II) is immobilized to Separopore® 4B following CNBr coupling. The final product is stabilized in a buffer to retain maximum activity. The gel can be packed in 1 mL or 5mL.

Technical Specifications

Abbreviation: SNA/EBL II
Material Source:: Elderberry bark
Conjugate:: Separopore® 4B
Shelf Life:: 1 year
Blood Group Specificity:: Non-specific
Preferred Sugar Specificity:: GalNAc, Galactose
Mitogenic Activity:: No
Lyophilized or Liquid: Liquid
Storage Temperature:: 2-8°C
Hazardous Shipping:: Non-hazardous

Applications

References

  • Inoue K, Wada J, Eguchi J, Nakatsuka A, Teshigawara S, Murakami K, et al. (2013) Urinary Fetuin-A Is a Novel Marker for Diabetic Nephropathy in Type 2 Diabetes Identified by Lectin Microarray. PLoS ONE 8(10): e77118. https://doi.org/10.1371/journal.pone.0077118
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