Narcissus pseudonarcissus Lectin (NPL/NPA) - Pure

Narcissus pseudonarcissus Lectin (NPL/NPA) - Pure

Price: Regular price $82.40

SKU#: 21510256-1

Product Description

Narcissus pseudonarcissus lectin or agglutinin (NPL/NPA) is affinity purified composed of four subunits. It agglutinates rabbit erythrocytes but is non-reactive with human erythrocytes. NPA has an isoelectric point between pH 4.2 and pH 4.6 with a specific binding activity toward α-D-mannose, although studies have suggested that the purified lectin may have greater affinity for internal mannosyl residues than for nonreducing terminal units. A buffer washed column elutes the sugar α-methylmannoside.

Human studies have found NPA to be nearly non-mitogenic, but it has been reported through an in vitro study that mitogenicity of NPA is age-related, with lymphoproliferative response of peripheral blood mononuclear cells (PBMC) in umbilical cord blood has a sevenfold increase than adult blood. NPA has also been found to be mitogenic for PBMC from lambs and not adult sheep.

Technical Specifications

Abbreviation: NPL/NPA
Material Source:: Lent lily
Conjugate:: None
Molecular Weight:: 59 kDa
Purity:: High Purity Grade
Shelf Life:: 2 years
Blood Group Specificity:: Rabbit
Preferred Sugar Specificity:: α-Mannose
Inhibiting or Eluting Sugar:: α-Methylmannoside
Mitogenic Activity:: No
Lyophilized or Liquid: Lyophilized
Storage Temperature:: -20°C
Hazardous Shipping:: Non-hazardous

Applications

Cancer biomarker, Agglutination studies, Characterization of early apoptosis stages

References

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