Datura stramonium Lectin (DSA/DSL) - Texas Red

Datura stramonium Lectin (DSA/DSL) - Texas Red
Datura stramonium (Jimson weed) Lectin (DSA/DSL) - Texas Red
Product image 1Datura stramonium Lectin (DSA/DSL) - Texas Red
Product image 2Datura stramonium (Jimson weed) Lectin (DSA/DSL) - Texas Red

Price: Regular price $144.98

SKU#: 21761014-1

Product Description

Datura stramonium agglutinin or lectin (DSA/DSL) is purified by affinity chromatography. Seeds of Datura stramonium contain at least three different carbohydrate-binding proteins, and the most prominent lectin is a dimeric glycoprotein composed of two nonidentical subunits that contains 40% carbohydrate. It binds well to N-acetylglucosamine, oligomers, and branched pentasaccharide, including two N-acetylglucosamine disaccharides linked to mannose (β-1,6) and (β-1,2), which is known to be the most potent inhibitor of agglutination. DSL prefers binding to (GlcNAc)2-4 and elutes with the sugar chitin hydrolysate. DSL binds well in the acidic pH range and its affinity decreases above pH 8.0. This agglutinin has blood group A, B, and O specificity. Studies have shown that DSA can act as a biomarker for neoplastic urotherial cells.

Texas Red is a red-fluorescent dye and when bound to Datura stramonium Lectin (DSA/DSL) can show the binding pattern of this lectin in cellular imaging applications. There is very little overlap between the emission spectra of Texas Red and FITC making this combination ideal for dual-labeling experiments. Rhodamine dyes, such as Texas Red, are more photostable and less sensitive to pH change when compared to other dyes such as fluorescein.

Technical Specifications

Abbreviation: DSA/DSL
Material Source:: Jimson weed
Conjugate:: Texas Red
Concentration:: 5 mg/mL
Purity:: High Purity Grade
Shelf Life:: 1 year
Blood Group Specificity:: Non-specific
Preferred Sugar Specificity:: (N-Acetylglucosamine)2-4
Inhibiting or Eluting Sugar:: Chitin Hydrolysate
Mitogenic Activity:: Yes
Lyophilized or Liquid: Liquid
Storage Temperature:: 2-8°C
Hazardous Shipping:: Non-hazardous

Applications

References

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