Datura stramonium Lectin (DSA/DSL) - Pure

Datura stramonium Lectin (DSA/DSL) - Pure

Price: Regular price $71.97

SKU#: 21510038-1

Product Description

Datura stramonium agglutinin or lectin (DSA/DSL) is purified by affinity chromatography. Seeds of Datura stramonium contain at least three different carbohydrate-binding proteins, and the most prominent lectin is a dimeric glycoprotein composed of two nonidentical subunits that contains 40% carbohydrate. It binds well to N-acetylglucosamine, oligomers, and branched pentasaccharide, including two N-acetylglucosamine disaccharides linked to mannose (β-1,6) and (β-1,2), which is known to be the most potent inhibitor of agglutination. DSL prefers binding to (GlcNAc)2-4 and elutes with the sugar chitin hydrolysate. DSL binds well in the acidic pH range and its affinity decreases above pH 8.0. This agglutinin has blood group A, B, and O specificity. Studies have shown that DSA can act as a biomarker for neoplastic urotherial cells.

Technical Specifications

Abbreviation: DSA/DSL
Material Source:: Jimson weed
Conjugate:: None
Molecular Weight:: 86 kDa
Appearance Form:: Powder
Appearance Color:: White to off white
Purity:: Affinity purified
Shelf Life:: 2 years
Blood Group Specificity:: A, B, O
Preferred Sugar Specificity:: (N-Acetylglucosamine)2-4
Inhibiting or Eluting Sugar:: Chitin Hydrolysate
Divalent Ions:: None Required
Mitogenic Activity:: Yes
Lyophilized or Liquid: Lyophilized
Storage Temperature:: -20°C
Hazardous Shipping:: Non-hazardous

Applications

Cancer biology, Glycobiology, Marker for mouse peritoneal cells

References

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