Viscum album Lectin (ML I/VAA) - Pure

Viscum album Lectin (ML I/VAA) - Pure

Price: Regular price $109.91

SKU#: 21511006-1

Product Description

Viscum album (ML I / VAA) lectin, is a Galactose-specific lectin. It is a dimer with a molecular weight of 115 kDa. ML-I is both a type II ribosome inactivating protein and a chitin-binding lectin. This lectin has additionally been shown to inhibit B cell hybridomas and P815, EL-4, Ke37, MOLT-4, and Up37 tumor cell lines by apoptosis induction.
Functionalized forms are available upon inquiry.

Technical Specifications

Abbreviation: ML I / VAA
Material Source:: Mistletoe
Conjugate:: None
Molecular Weight:: 115 kDa
Appearance Form:: Powder
Appearance Color:: White to off-white
Purity:: Affinity-purified
Shelf Life:: 2 years
Blood Group Specificity:: Human erythrocytes, no specificity for A, B, or O blood groups
Preferred Sugar Specificity:: Galactose, N-Acetylgalactosamine
Inhibiting or Eluting Sugar:: N-Acetylgalactosamine
Divalent Ions:: None Required
Lyophilized or Liquid: Lyophilized
Storage Temperature:: -20ºC
Hazardous Shipping:: Non-hazardous

Applications

References

  • Sweeney, E. C., Tonevitsky, A. G., Palmer, R. A., Niwa, H., Pfueller, U., Eck, J., ... & Kirpichnikov, M. P. (1998). Mistletoe lectin I forms a double trefoil structure. FEBS letters431(3), 367-370.
  • Franz, H., Ziska, P., & Kindt, A. (1981). Isolation and properties of three lectins from mistletoe (Viscum album L.). Biochemical journal195(2), 481-484.
  • Galanina, O. E., Kaltner, H., Khraltsova, L. S., Bovin, N. V., & Gabius, H. J. (1997). Further refinement of the description of the ligand‐binding characteristics for the galactoside‐binding mistletoe lectin, a plant agglutinin with immunomodulatory potency. Journal of Molecular Recognition10(3), 139-147.
  • Janssen, O., Scheffler, A., & Kabelitz, D. (1993). In vitro effects of mistletoe extracts and mistletoe lectins. Cytotoxicity towards tumor cells due to the induction of programmed cell death (apoptosis). Arzneimittel-Forschung43(11), 1221-1227.
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