Psophocarpus tetragonolobus Lectin (PTL/PTA I+II) - Pure

Psophocarpus tetragonolobus Lectin (PTL/PTA I+II) - Pure

Price: Regular price $80.72

SKU#: 21511410-1

Product Description

Psophocarpus tetragonolobus lectin (PTL, psophocarpin B1, a storage protein with chymotrypsin inhibitory activity), is isolated from winged bean seeds and purified by affinity chromatography. The seed contains two lectins in which PTL I is the basic and PTL II is the acidic of the two.

PTL is a dimeric glycoprotein with specificity to GalNAc, with eluting sugar GalNAc. This lectin agglutinates trypsinized rabbit and human erythrocytes (types A,B, and O). PTL I recognizes blood group A-substance derived oligosaccharides such as trisaccharide GalNAc?1-3Gal?1-4Glc. Nonpolar interactions play an important role in stabilization of the lectin-sugar complex. Projection of α1,3 linked Gal/GalNAc leads to steric hindrance and prevents the binding of blood group A and B reactive sugars. The unique specificity of PTL II makes it to be useful in isolation and characterization of terminally monofucosylated H-reactive oligosaccharides from those that are difucosylated or internally fucosylated.

 

Technical Specifications

Abbreviation: PTL/PTA I+II
Material Source:: Winged bean
Conjugate:: None
Molecular Weight:: 58 kDa
Shelf Life:: 2 years
Preferred Sugar Specificity:: N-Acetylgalactosamine, Galactose
Inhibiting or Eluting Sugar:: N-Acetylgalactosamine
Divalent Ions:: Ca++, Mn++
Mitogenic Activity:: No
Storage Temperature:: -20°C
Hazardous Shipping:: Non-hazardous

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References

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