Polygonatum odoratum Lectin (POL) - Pure

Polygonatum odoratum Lectin (POL) - Pure
Polygonatum odoratum (Solomon's Seal) Lectin (POL) - Pure
Product image 1Polygonatum odoratum Lectin (POL) - Pure
Product image 2Polygonatum odoratum (Solomon's Seal) Lectin (POL) - Pure

Price: Regular price $213.74

SKU#: 21511430-1

Product Description

Affinity-purified Polygonatum odoratum(POL)lectin, isolated from the Chinese medicine herb (Mill.) Druce, shows anti-tumor activity, including apoptosis- and autophagy-inducing properties determined by cellular morphology observation, flow cytometry, and immunoblotting. This lectin is a homo-tetramer linked by non-covalent bonds and has a molecular weight of 11953.623 Da per subunit. POL simultaneously induces apoptosis and autophagy in human non-small cell lung cancer cells. This lectin inhibits the Akt-NF-kB pathway while triggering autophagy via suppressing the Akt-mTOR pathway. POL displays no significant cytotoxicity toward normal human embryonic lung fibroblast HELF cells. Due to its anti-tumor activities, this mannose and sialic acid-binding lectin may become a potent anti-cancer drug in future therapies.
Functionalized forms are available upon inquiry.

Technical Specifications

Abbreviation: POL
Material Source:: Solomon's Seal
Conjugate:: None
Molecular Weight:: 11.9 kDa
Appearance Form:: Powder
Appearance Color:: White to off-white
Purity:: Affinity-purified
Shelf Life:: 2 years
Blood Group Specificity:: Rabbit erythrocytes
Preferred Sugar Specificity:: Mannose
Inhibiting or Eluting Sugar:: Mannose
Lyophilized or Liquid: Lyophilized
Storage Temperature:: -20ºC
Hazardous Shipping:: Non-hazardous

Applications

References

  • Yang, Y., Xu, H. L., Zhang, Z. T., Liu, J. J., Li, W. W., Ming, H., & Bao, J. K. (2011). Characterization, molecular cloning, and in silico analysis of a novel mannose-binding lectin from Polygonatum odoratum (Mill.) with anti-HSV-II and apoptosis-inducing activities. Phytomedicine18(8-9), 748-755.
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