Polygonatum cyrtonema Lectin (PCL) - Pure
Price: Regular price $221.22
Product Description
Polygonatum cyrtonema(PCL) lectin is a mannose/sialic acid-binding lectin that displays significant inhibitory and cytotoxic activity toward cancer cells. PCL was shown to markedly inhibit the growth of human melanoma A375 cells. It was also found to simultaneously induce A375 cell apoptosis and autophagy. The mechanism of apoptosis following treatment with PCL involves regulation of the Bax, Bcl-xL and Bcl-2 proteins, which then cause collapse of the mitochondrial membrane potential. PCL also abrogates the glutathione antioxidant system and induces mitochondria to generate massive ROS accumulation. PCL was additionally found to induce human melanoma A375 cell apoptosis, as evidenced by morphological and ultrastructural changes.
Functionalized forms are available upon inquiry.
Technical Specifications
| Abbreviation | : | PCL |
| Material Source: | : | Giant Chinese Solomon's Seal |
| Conjugate: | : | None |
| Molecular Weight: | : | Not determined |
| Appearance Form: | : | Powder |
| Appearance Color: | : | White to off-white |
| Purity: | : | Affinity-purified |
| Shelf Life: | : | 2 years |
| Blood Group Specificity: | : | Not determined |
| Preferred Sugar Specificity: | : | Mannose, Sialic Acid |
| Inhibiting or Eluting Sugar: | : | Mannose |
| Divalent Ions: | : | None Required |
| Mitogenic Activity: | : | No |
| Lyophilized or Liquid | : | Lyophilized |
| Storage Temperature: | : | -20ºC |
| Hazardous Shipping: | : | Non-hazardous |
Applications
References
- Liu, B., Cheng, Y., Bian, H. J., & Bao, J. K. (2009). Molecular mechanisms of Polygonatum cyrtonema lectin-induced apoptosis and autophagy in cancer cells. Autophagy, 5(2), 253-255.
