Polygonatum cyrtonema Lectin (PCL) - Pure

Polygonatum cyrtonema Lectin (PCL) - Pure
Polygonatum cyrtonema (Giant Chinese Solomon's Seal) Lectin (PCL) - Pure
Product image 1Polygonatum cyrtonema Lectin (PCL) - Pure
Product image 2Polygonatum cyrtonema (Giant Chinese Solomon's Seal) Lectin (PCL) - Pure

Price: Regular price $221.22

SKU#: 21511429-1

Product Description

Polygonatum cyrtonema(PCL) lectin is a mannose/sialic acid-binding lectin that displays significant inhibitory and cytotoxic activity toward cancer cells. PCL was shown to markedly inhibit the growth of human melanoma A375 cells. It was also found to simultaneously induce A375 cell apoptosis and autophagy. The mechanism of apoptosis following treatment with PCL involves regulation of the Bax, Bcl-xL and Bcl-2 proteins, which then cause collapse of the mitochondrial membrane potential. PCL also abrogates the glutathione antioxidant system and induces mitochondria to generate massive ROS accumulation. PCL was additionally found to induce human melanoma A375 cell apoptosis, as evidenced by morphological and ultrastructural changes.
Functionalized forms are available upon inquiry.

Technical Specifications

Abbreviation: PCL
Material Source:: Giant Chinese Solomon's Seal
Conjugate:: None
Molecular Weight:: Not determined
Appearance Form:: Powder
Appearance Color:: White to off-white
Purity:: Affinity-purified
Shelf Life:: 2 years
Blood Group Specificity:: Not determined
Preferred Sugar Specificity:: Mannose, Sialic Acid
Inhibiting or Eluting Sugar:: Mannose
Divalent Ions:: None Required
Mitogenic Activity:: No
Lyophilized or Liquid: Lyophilized
Storage Temperature:: -20ºC
Hazardous Shipping:: Non-hazardous

Applications

References

  • Liu, B., Cheng, Y., Bian, H. J., & Bao, J. K. (2009). Molecular mechanisms of Polygonatum cyrtonema lectin-induced apoptosis and autophagy in cancer cells. Autophagy5(2), 253-255.
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