Phaseolus vulgaris Lectin (PHA-L) - Separopore® 6B SuperTrap™ Cartridge

Phaseolus vulgaris (Kidney bean) Lectin (PHA-L) - OnePASS™ Separopore® 4B Column (Fast Flow)

Price: Regular price $139.26

SKU#: 30330035-1

Product Description

Phaseolus vulgaris lectin (PHA-L) is affinity purified lectin made up of four subunits with carbohydrate specificity for complex oligosaccharides. PHA-L is known as leucoagglutinin and has high mitogenic and leucoagglutinating activity, and low erythroagglutinating activity. This lectin exhibits no agglutination with human erythrocytes. PHA-E differs from PHA-L in that the leucoagglutinin reacts strongly with Tamm-Horsfall glycoprotein and reacts weakly with porcine thyroglobulin. PHA-L binds to fetuin but does not precipitate the glycoprotein. This lectin is strongly inhibited by trisaccharide Gal β(1,4)GlcNAcβ(1,2)Man, and although this structure is present in many glycoproteins, PHA-L does not react with all of them. This lectin reacts strongly with certain carcinoma cell lines of high metastatic potential and has been proposed as a probable therapeutic agent. It has shown potential to inhibit graft vs. host reaction in transplantation studies and has also shown to promote the production of cytotoxic agents which could be useful in cancer therapy. bioWORLD produces crosslinked 6B Separopore® appropriately coupled to Phaseolus vulgaris Lectin (PHA-L) to provide a fast flow cartridge which can trap affinity bound material and retain it during washing, followed by elution of affinity purified material. bioWORLD’s SuperTrap cartridges of varies matrices are proven highly effective in protein chromatography.

Technical Specifications

Purity:: High Purity Grade
Shelf Life:: 1 year
Storage Temperature:: 2-8°C
Hazardous Shipping:: Non-hazardous

Applications

References

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