Griffonia simplicifolia Lectin (GSL I) - Ferritin

Griffonia simplicifolia Lectin (GSL I) - Ferritin
Griffonia simplicifolia (Bandeiraea) Lectin (GSL I) - Ferritin
Product image 1Griffonia simplicifolia Lectin (GSL I) - Ferritin
Product image 2Griffonia simplicifolia (Bandeiraea) Lectin (GSL I) - Ferritin

Price: Regular price $89.70

SKU#: 21761191-1

Product Description

Griffonia simplicifolia lectin (GSL I) is affinity purified from a woody climbing shrub native to Africa. GSL I is composed of two types of subunits A and B that combine to form tetrameric structures, resulting in five isolectins. This lectin has affinity for terminal α-D-galactosyl residues and terminal N-acetyl-α-D-galactosaminyl residues. The A-rich lectin preferentially agglutinates blood group A erythrocytes and thus appears to be specific for α-N-acetylgalactosamine residues, while the B-rich lectin preferentially agglutinates blood group B cells and is specific for α-galactose residues. This lectin shows specificity for blood group B greater than blood group A1.
GSL I has been reported to bind several glycoproteins including laminin. Since some α-D-galactosyl residues are expressed in endothelial cells of mouse tissues, GSL I can present a highly specific surface of glycosylation pattern in these cells.

Griffonia simplicifolia Lectin (GSL I) is conjugated to ferritin, that has a molecular weight of 474,000 g/mol (all 24 subunits combined). Ferritin-conjugated lectins can be used to visualize localization of specific saccharide moieties and examine the distribution of plasma membrane glycoproteins. These conjugates can be viewed via electron microscopy.

Technical Specifications

Abbreviation: GSL I
Material Source:: Bandeiraea
Conjugate:: Ferritin
Concentration:: 1 mg/mL
Shelf Life:: 1 year
Blood Group Specificity:: Non-specific
Preferred Sugar Specificity:: α-Galactose, α-N-Acetylgalactosamine
Inhibiting or Eluting Sugar:: Galactose, N-Acetylgalactosamine
Divalent Ions:: Ca++, Mn++
Mitogenic Activity:: No
Lyophilized or Liquid: Liquid
Storage Temperature:: -20°C
Hazardous Shipping:: Non-hazardous

Applications

References

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