Arachis hypogaea Lectin (PNA) - Colloidal Gold

Arachis hypogaea Lectin (PNA) - Colloidal Gold
Arachis hypogaea (Peanut) Lectin (PNA) - Colloidal Gold
Product image 1Arachis hypogaea Lectin (PNA) - Colloidal Gold
Product image 2Arachis hypogaea (Peanut) Lectin (PNA) - Colloidal Gold

Price: Regular price $155.41

SKU#: 21510800-1

Product Description

Arachis hypogaea agglutinin (PNA) is purified by affinity chromatography and is consisting of four subunits of approximately 27,000 each. This lectin has an isoelectric point between pH 5.5 and pH 6.5. It has a carbohydrate specificity for Galβ3GalNAc with an eluting sugar of galactose. Galactose and lactose are poor inhibitors while disaccharide Gal β(1->3)GalNAc and desialylated human erythrocyte N-substance (T-antigen which is present in many M and N blood groups) are potent inhibitors of PNA.

Although extracts of Arachis hypogaea do not agglutinate untreated or trypsin-treated human erythrocytes, PNA has been known to agglutinate neuraminidase-treated human red blood cells. PNA may be used for clinical determination of T-polyagglutinability of erythrocytes and probing cell membranes of normal and malignant cells. This lectin can be of use in characterization of tumor-specific antigens on the surface of malignant cells. It can be employed in the fractionation of stem cells in mice for use in bone marrow transplantation across histocompatibility barriers.

Colloidal gold can be used to visualize localization of specific saccharide moieties and examine the distribution of plasma membrane glycoproteins based on the binding pattern of Arachis hypogaea (Peanut) Lectin (PNA). Colloidal gold labeled lectins can be viewed via electron microscopy.

Technical Specifications

Abbreviation: PNA
Material Source:: Peanut
Conjugate:: Colloidal Gold
Concentration:: 1 mg/mL
Purity:: High Purity Grade
Shelf Life:: 1 year
Blood Group Specificity:: Non-specific
Preferred Sugar Specificity:: Galβ3GalNAc
Inhibiting or Eluting Sugar:: Galactose
Divalent Ions:: Ca++, Mg++
Excitation:: 550 nm
Emission:: 570 nm
Mitogenic Activity:: No
Lyophilized or Liquid: Liquid
Storage Temperature:: 2-8°C
Hazardous Shipping:: Non-hazardous

Applications

References

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